Effect of ciprofloxacin on mitogen-stimulated lymphocyte proliferation

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Effect of ciprofloxacin on mitogen-stimulated lymphocyte proliferation.

Ciprofloxacin was tested for its inhibitory or stimulatory effects on concanavalin A- and phytohemagglutinin-stimulated proliferation (measured by [3H]thymidine uptake) of human peripheral blood mononuclear cells and murine splenocytes. Ciprofloxacin did not diminish or enhance mononuclear cell proliferation at concentrations of 5 to 125 micrograms/ml. Further, the proliferative response of spl...

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evaluation of proliferation and cytokines production by mitogen-stimulated bovine peripheral blood mononuclear cells

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Effect of Pokeweed Mitogen (pwm) on Lymphocyte Lysosomes

Resting blood lymphocytes in vitro undergo transformation into large, blastlike, dividing cells following incubation with phytohemagglutinin (PHA), a plant lectin from Phaseolus vulgaris (1). Farnes et al. (2) found another phytomitogen in saline extracts of the plant Phytolacca americana (pokeweed). Although both PHA and the pokeweed mitogen (PWM) induce nonspecific transformation of lymphocyt...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1986

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.29.2.337